The Church of Iomedae is assertive and vigilant in rooting out evil. Many of its followers are actively involved in the Mendevian Crusades. In fact, the threat of the Worldwound gave the church a purpose—finish the task Aroden started years ago and finally defeat Deskari, the demon lord believed to be behind the opening of the portal to the Abyss. The church founded the First Mendevian Crusade in 4622 AR as a way to lessen the loss of Aroden, becoming zealots. Besides Mendev, Iomedae's faithful are also found in greater numbers in Absalom, Andoran, Cheliax, Galt, Lastwall, Molthune, Nirmathas, Numeria, and Sargava, and among Chelaxians, Taldans, and halflings throughout the Inner Sea region.
Having inherited many of Aroden's faithful, Iomedae and her priests continue to promote his teachings, although they tend to be more progressive in their thinking than he ever was, and feel themselves less inhibited by the events of history.